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PTSD in women may have genetic link

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first_img 95 Views   no discussions Share Sharing is caring! CNN News Share Tweet After a single traumatic event, as many as one-fourth of people exposed will develop post-traumatic stress disorder, a psychiatric disorder characterized by anxiety, hyperarousal and persistent unwanted memories.Scientists are looking for genes or gene pathways that can help better predict PTSD. A new study in the journal Nature suggests one such route in women: through a protein called pituitary adenylate cyclase-activating polypeptide, which is known to regulate the cellular stress response. Women are more likely to have PTSD in general; 10% of women and 5% of men develop the condition sometime in their lives.Participants, of which there were more than 1,200, came from an impoverished area around Atlanta, Georgia, and did not have military-related trauma. Interpersonal violence, gunshot violence, sexual assaults and other abuse were some of the triggers of PTSD reported.Study results suggest that a particular gene variant for PACAP may be sensitive to both estrogen and stress, because it is associated with women who have PTSD.“It helps us to understand that PTSD is complex,” said Dr. Kerry Ressler of Emory University School of Medicine, lead study author. “There are many individual ways that people come to PTSD, in the same way that there are probably 100 different ways to come down with heart failure.”This is probably one of many biological pathways that lead to PTSD, he said. Understanding it will help get a better picture of the biology and the neural circuitry of PTSD, and could have implications for future diagnosis and treatment of the condition.Ressler’s group found that this gene variant is highly associated with all three subcategories of PTSD: hyperarousal, intrusive memories and avoidant behavior. It could be broadly linked to all of them, or perhaps the definition of PTSD is not specific enough to what’s going on biologically, Ressler said.In rodents, the parts of the brain associated with fear and stress alter the regulation of these genes with fear learning. This could be happening in humans also, he said.The gene variant described in the research influences the key human stress response system, which is central to PTSD and so it makes clinical sense that it would be involved, said Dr. John Markowitz, PTSD researcher at Columbia University College of Physicians and Surgeons, who is not a geneticist but offered his clinical perspective on the research.But, Markowitz cautioned, in an e-mail, “the history of psychiatric genetics is littered with findings subsequently retracted or not borne out.” This particular study, which he called an “elegant research report,” has results that apply only to an estrogen gene in chronically traumatized women.There is more work to be done to examine the roots of PTSD in men, and there may be other pathways involved in women with acute trauma, Markowitz said. Another next step would be to examine whether the results of this study are consistent in members of the military. Share HealthLifestyle PTSD in women may have genetic link by: – February 25, 2011last_img read more

Arsenal Chief Bags UEFA Executive Committee Sit

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first_img“UEFA’s member associations ratified two representatives of the European Club Association (ECA) to sit on the UEFA Executive Committee as full members for a four-year term of office: Andrea Agnelli (Juventus FC/Italy) and Ivan Gazidis (Arsenal FC/England).” UEFA’s official website stated.RelatedUEFA to Launch Third Tier European Competition Alongside Champions League and Europa LeagueDecember 3, 2018In “Europe”Čeferin To Return As UEFA PresidentNovember 10, 2018In “Europe”CAS: Manchester City 2-Year Champions League Ban OverturnedJuly 13, 2020In “England” Arsenal Chief Executive, Ivan Gazidis has been officially appointed as a member of UEFA’s Executive Committee on a four-year term.Following UEFA’s 13th Extraordinary Congress in Geneza, Switzerland, Gazidis, and Chairman of Italian giants Juventus, Andrea Agnelli were “ratified” into the executive committee as representatives of the European Club Association (ECA).last_img read more

Hearts coach David Duncan drops exit hint

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first_imgHead coach of Ghanaian top flight side Hearts of Oak David Duncan has revealed that he is not happy at the club and says it is possible he might leave at the end of the season.Speculations of his resignation at the end of the season are rife in the local media and speaking to Asempa FM’s Kofi Asare Brako on the ultimate sports show, the former Ghana national U-23 coach did not rule that out.“I am at the apex of my coaching career domestically and coaching Accra Hearts of Oak is the highest point,” Duncan said.“I am having some challenges but I am not the type of person who suffers in silence. I let it out and to anybody who has the right to know and the people who have the right to know are not only my employers.“I let anyone who asks me about my job know the truth. I am not a hypocrite to say I am happy if I am not.“I express my frustrations, my challenges and if things continue this way, we might not meet the target we have set for ourselves and I don’t want to be held responsible for it and if push comes to shove, I will do the honorable thing.” Duncan’s performance has earned rave reviews after taking the club from a relegation position to compete for a top four finish.last_img read more

NHL trade rumors: Senators, Maple Leafs have ‘tentative’ deal in place for Nikita Zaitsev

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first_imgThere is belief that Cody Ceci could be heading back in return. Would make sense if it was processed after Zaitsev’s $3M bonus is paid July 1. https://t.co/AJ31P49MGh— Chris Johnston (@reporterchris) June 29, 2019According to TSN, there is a tentative deal in place, but there may be a couple of pieces added in the coming days.TOR and OTT appear to have a tentative trade in place that would send Nikita Zaitsev to OTT in exchange for Cody Ceci. There may be another part or parts to it but the deal can’t be finalized until July 1, when TOR pays Zaitsev’s $3M signing bonus.— Bob McKenzie (@TSNBobMcKenzie) June 30, 2019Zaitsev, 27, has five years remaining on the seven-year, $31.5 million deal he signed with Toronto in 2017. The Senators also appear to be on his no-trade list, so that could complicate things going forward.Zaitsev has not been asked to waive. Could be a formality, however his relationship with DJ Smith could help make this happen. https://t.co/4mnj7B7CBp— Darren Dreger (@DarrenDreger) June 29, 2019Zaitsev has fallen off significantly since signing his current deal as he had 36 points (four goals, 32 assists) in 2016-17 and has combined for eight goals and 19 assists since.His plus-minus has gotten significantly better in that time as he went from minus-22 to plus-10, but his ice time has also gone down somewhat, and his contract demands more out of him on the offensive end even if he is a defenseman.The Maple Leafs also want to re-sign restricted free agent Mitch Marner who is due a massive payday this year.Getting rid of Zaitsev’s deal would go a long way in helping that.For the Senators, after they lost Erik Karlsson in a trade to the Sharks last year, they have added a couple defensemen to help make up for his loss. The report states the deal might not happen for a couple of days, but it is being discussed nonetheless.Hearing OTT/TOR are working on a Zaitsev deal. Might not happen for a couple of days, but it’s in the process.— Elliotte Friedman (@FriedgeHNIC) June 29, 2019It would appear as well that Cody Ceci would be coming back to the Maple Leafs in return. Related News NHL trade rumors: Oilers have contacted Hurricanes about Petr Mrazek The Senators may be close to adding another defenseman.According to Hockey Night in America, Ottawa is discussing a deal for Toronto’s Nikita Zaitsev. NHL trade rumors: Sabres have contacted Rangers about Jimmy Vesey Ottawa received top defenseman prospect Erik Brannstrom in a deal with the Golden Knights in return for forward Mark Stone.The team already has a stud in Thomas Chabot on its blue line and Brannstrom is the next man up in making the team’s defense formidable for years to come.Zaitsev would only help with the team’s depth going forward in what looks to be a lengthy rebuild. NHL trade rumors: Canucks acquire center J.T. Miller from Lightninglast_img read more